Assembling large genomes with single-molecule sequencing and locality-sensitive hashing 好好读读,算法系列的好文章! Assembling large genomes with single-molecule sequencing and locality-sensitive hashing - NATURE BIOTECHNOLOGY marbl/MHAP - Github MinHash Alignme
总是跑数据,却对数据一无所知,这说不过去吧. 看几篇文章吧 Sequencing depth and coverage: key considerations in genomic analyses(只讲二代) Assembly of large genomes using second-generation sequencing(参考文献) Identification of optimum sequencing depth especially for de novo genome asse
柳叶刀发表的文献解读:Whole-exome sequencing in the evaluation of fetal structural anomalies: a prospective cohort study 背景介绍 随着超声波在产科护理中的应用,胎儿结构异常的鉴别已成为例行公事.当发现异常时,进一步评估核型.全染色体非整倍体与染色体微阵列(CMA)上较小的微缺失和复制(CNV),则是非常的重要.目前研究发现,大约32%结构异常胎儿具有临床相关的异常核型,6%的结构异常胎儿能找到致病