using System;

using System.Collections.Generic;

using System.Text;

using System.Diagnostics;

using System.Reflection;

using System.Runtime.InteropServices;

using System.Windows.Forms;

namespace WindowsFormsApplication4

{

   public  class MultiRunChecker{

      public   static bool  hasMultiRun()

        {

            Process[] ps = Process.GetProcessesByName(Assembly.GetExecutingAssembly().GetName().Name);

            if (ps != null && ps.Length > 1)

            {

                //发现重复进程

                return true;

            }

            return false;

        }

    }

}

调用：

//防止改名运行

 if (!Application.ExecutablePath.EndsWith(Assembly.GetExecutingAssembly().GetName().Name+".exe")) {

                MessageBox.Show("app not valid");

                Application.Exit();

            }

            if (MultiRunChecker.hasMultiRun()) {、、防止多个程序运行

                MessageBox.Show("has");

                Application.Exit();

            }